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Re: The Infamous "Amoxil Rash"

I remember reading an article (Contemporary Pediatrics?) that stated delayed reactions (ie not within minutes to hours) whether allergic in nature or not, do not increase risk of anaphylactic reaction to subsequent exposure.

Eve H. Switzer, MD
rural peds

On Sun, 17 February 2002, Michael Sachs wrote:

>
> >In a message dated 2/14/2002 1:40:45 PM Eastern Standard Time,
> > writes:
> >
> >
> > > Anyone have any information on the infamous "Amoxil (amoxicillin) rash"?
>
>
>
> >At 04:31 PM 2/17/02 -0500,  wrote:
> >No data, but I certainly see it.  That's why I ask lots of questions when
> >parents tell me their child is allergic to something.  You really have to
> >find out what kind of reaction they had.  Many tell me they vomited, or had
> >some diarrhea, or something else like that.  Rashes are tougher, because they
> >don't always remember what it looked like or whether it itched.  If I'm not
> >really sure, I let them know that testing is available for penicillin
> >allergy.
> >
> >Moshe Adler, MD
>
>
> I seem to recall reading somewhere that 70-80% of people who report a
> penicillin allergy actually are not allergic.
>
> Sometimes when I'm pretty confident that a non-urticarial rash is likely
> one of these idiosyncratic Amoxil rashes or maybe a non-specific viral
> exanthem I'll try Amoxil again at some point in the future.  I've rarely
> seen the rash duplicated on a subsequent course of Amoxil.
>
> So here's a question back to the list:  If a child has had a non-severe,
> non-specific, non-systemic, non-urticarial rash associated with Amoxil in
> the past, is there likely to be a significant risk of anaphylaxis with
> trying another course before doing formal skin or RAST testing?  Any opinions?
>
>
>
> Michael Sachs, M.D.
> General Pediatrician
>

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