Nix on the ASA to prevent altitude sickness. Altitude sickness is unlikely at altitudes under 8,500 feet. Tell the parents that the kids are unlikely to have symptoms. They should be prepared, though, to take it easy on strenuous activity the first couple of days and see how the family acclimates. Also drink some extra fluids, get some extra rest, and no alcohol at first. Both acetazolamide and dexamethasone have been used to prevent altitude sickness, but neither is warranted for the case you describe. Here's a real nice review for you: Johnson TS, Rock PB: Acute mountain sickness. NEJM 1988;319:841-845. Also, from that article: "Aspirin, naproxen, amphetamines, codeine, and phenytoin have not proved to be beneficial in the prevention or treatment of acute mountain sickness." Bob Mauro, MD Greenwood Pediatrics Littleton, CO (5,900 ft above sea level and loving it)