~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ This message is from PedTalk! To reply to the group, use "" ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ ---------- > Van: Robert Shayne <> > Aan: > Onderwerp: CMV > Datum: donderdag 27 november 1997 3:23 > > ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ > This message is from PedTalk! To reply to the group, use "" > ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ > I don't have much experience with using Gangliocivir, but I had some > questions about your evaluation. > Thrombocytopenia, as you probably know, is part of the TORCHS cluster. > Your patient might have a positive CMV culture from pre-natally acquired > CMV. Are there any other signs of pre-natally acquired CMV (microcephaly, > hepatosplenometally, pneumonia, rash). The importance of distinguishing is > that certain consequences of CMV (especially hearing loss) have lifelong > implications. > Thank you for the remarks. True, I did not mention that he is IgM positive, IgG negative for CMV-antibodies. Mom is IgG positive, IgM negative. ALAT and ASAT slightly raised, but no hepatosplenomegaly. BEAR-results pending. In fact the question is whether to try and treat with immune-globulins. Does anyone have experience. The Red Book (1991 edition) only recommends ganciclovir treatment i.c.o. chorioretinitis from acquired infection in the immune-compromised and states it is usefulness in other organ-involverment as well. However one of the side effects could be thc-penia from bone-marrow toxicity The other question is: how long will it take to resolve spontaneously? Any suggestions? Jaap Karsten, general paediatrican De Sionsberg Dokkum The Netherlands